This page provides links to resources and papers mentioned in my presentation of the recent modelling and research activities of Blue Brain.


Resources

Data and portals

https://portal.bluebrain.epfl.ch - The main data portal containing neuron and synapse models

https://bbp.epfl.ch/nmc-portal/downloads - Download the predicted rat local connectome

http://channelpedia.epfl.ch - Ion channel models and tons of data on ion channel kinetics

https://portal.bluebrain.epfl.ch/resources/models/mouse-projections/ - Predicted mouse connectome, comprising local and long-range connectivity

https://bbp.epfl.ch/nexus/cell-atlas - an atlas of the predicted whole-brain composition of adult mouse

https://reimann.science/2021/01/07/rat-somatosensory-cortex-connectivity/ - A neat visualization of our predicted rat connectome. Play around with it!

Code and programs

https://github.com/BlueBrain/BluePyOpt - General optimization framework. Used for building single cell electrical models

https://github.com/BlueBrain/insilico-vsdi - Used for calculating the VSDI signal from simulation results

https://github.com/BlueBrain/topological_sampling - Analysis code related to the Reimann et al., 2020 paper on spike coding. The raw data of that publication can be found at https://zenodo.org/record/4317336

https://github.com/MWolfR/targeting_specificity_test - A quick analysis showing the importance of statistical dependence when selecting synapses as a subset of potential synapses

Publications

Modelling / anatomy

Reconstruction and Simulation of Neocortical Microcircuitry - Cell, 2015

A Derived Positional Mapping of Inhibitory Subtypes in the Somatosensory Cortex - Frontiers in Neuroanatomy, 2019

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex - Frontiers in Neural Circuits, 2015

A Cell Atlas for the Mouse Brain - Frontiers in Neuroinformatics, 2018


Modelling / single-cell electrical

Reconstruction and Simulation of Neocortical Microcircuitry - Cell, 2015

BluePyOpt: Leveraging Open Source Software and Cloud Infrastructure to Optimise Model Parameters in Neuroscience - Frontiers in Neuroinformatics, 2016

Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons, PLOS Computational Biology, 2019


Micro-connectomics

Reconstruction and Simulation of Neocortical Microcircuitry - Cell, 2015

An algorithm to predict the connectome of neural microcircuits - Frontiers in Computational Neuroscience, 2015

Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits - PNAS, 2012

Neuron Geometry Underlies Universal Network Features in Cortical Microcircuits - bioRxiv, 2020

A synaptic organizing principle for cortical neuronal groups - PNAS, 2011


Synaptic physiology

Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex - Frontiers in Synaptic Neuroscience, 2019

A calcium-based plasticity model predicts long-term potentiation and depression in the neocortex - bioRxiv, 2020

Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity - Frontiers in Neural Circuits, 2018


Simulation project: Voltage-sensitive dye imaging

Voltage-sensitive dye imaging reveals inhibitory modulation of ongoing cortical activity - bioRxiv, 2019


Simulation project: Auditory surprise

Dense Computer Replica of Cortical Microcircuits Unravels Cellular Underpinnings of Auditory Surprise Response - bioRxiv, 2020


Simulation project: Coding and its limitations

Cortical reliability amid noise and chaos - Nature Communications, 2019

Impact of higher order network structure on emergent cortical activity - Network Neuroscience, 2020

Topology of synaptic connectivity constrains neuronal stimulus representation, predicting two complementary coding strategies - bioRxiv, 2020


Simulation project: Plasticity

A calcium-based plasticity model predicts long-term potentiation and depression in the neocortex - bioRxiv, 2020


Simulation project: Neuromodulation

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex - Frontiers in Neural Circuit, 2019

Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity - Frontiers in Neural Circuits, 2018